It seems obvious that persistent lesions might affect the nervous system and compromise the body as a whole.  But how would this work exactly?

It is important to remember that no wound ever heals completely, even if it disappears or returns to normal function. Normal wound healing and tissue repair is a complex and amazing process, but it is not perfect.  The nerves in the area remain sensitized, particularly the free nerve endings that determine how nociceptors and sympathetic nerves function.  Studies have shown that there are more of these in areas where prior injuries have occurred, and they are more prone to firing.  

These nerve endings live in skin and connective tissue, including the superficial fascia that holds muscles, nerves and vessels in place under the skin, and the deep fascia that holds muscles and organs together and guides their movement.  Native tissue is smooth, regular and symmetrical, sliding easily as a unit, but after injury the collagen fibers are thicker, with rough surfaces that create friction and can get stuck together, and overall these are like knots in wood.  They restrict movement and limit strength, but they also irritate the nerves that can get stuck in their path.

Nerves play a very significant role in regulating homeostasis, but they don’t do it alone.  They orchestrate a symphony of hormones, immune cells, cytokines and other factors, triggering thoughts, emotions and behaviours that regulate inflammation, stress, organ function, and create hunger, thirst, fatigue and other drives that guide our actions throughout the day.  What I call the PINE system includes our psychological, immune, nervous and endocrine systems, and when the stress response is triggered by our blockages, it affects the PINE system as a whole.